Prototype
Prototype is dull to start, shines brightly in the middle, then fades into needless frustration toward the end. There is some real fun here, like hijacking helicopters with a biological grappling hook (awesome), but it's seriously clouded by a generally boring overworld, terrible story, and questionable tuning in boss encounters.
I think the heart of the problem is, specifically, that you are a mutated super-man. Individual enemies pose no threat to you unless they're also hideously overpowered, or come in enormous numbers. And some design mis-steps in the way of uninterruptible attacks, and an indescribably bad targeting system, keep the playing field from ever really feeling even. When I wasn't slaughtering enemies without a second thought, I was being pounded by a downpour of bullets and rockets.
If you're really thirsting for open-world mayhem, Prototype has a sizeable amount of that, but having barely scratched the surface of side-missions and the Web of Intrigue I found them completely un-compelling. I would much rather hijack cars and drive them off bridges.
Progress: Finished Story on Normal